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Iated immune [58] responses . Subviral particles, genetically engineered plant viruses, insect-derived virus-likeIated immune [58] responses . Subviral particles, genetically engineered plant viruses, insect-derived virus-like particles, are suitable as presentation scaffold and adjuvant platform for multimeric display of foreign antigens in a correct, ordered and highly repetitive three-dim
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4]. Related to the OI story, the serpins, proteins which regulate protease activities, are IDPs, and serpin F1 mutations are associated with type V OI [153]. Another possible example of defective IDPs leading to bone disease is osteoporosis which has been associated with defects in osteonectin [156], which, as noted above has IDP regions. Osteopontin deficiency results in dystrophic calcification
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Ovide [40] biological compatibility with less toxicity . According to the structural organizationOvide [40] biological compatibility with less toxicity . According to the structural organization, biodegradable nanoparticles are usually distinguished in nanospheres, where molecules are homogenously dispersed, adsorbed or dissolved within the polymeric matrix, and nanocapsules, where a polymer
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Noeud5, Raghu Metpally4, Eric M Thompson1,3, J Robert Manak4, Anders Goks r3 and Daniel Chourrout1*AbstractBackground: Animals have developed extensive mechanisms of response to xenobiotic chemical attacks. Although recent genome surveys have suggested a broad conservation of the chemical defensome across metazoans, global gene expression responses to xenobiotics have not been well investigated in
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The OPN KO animals had a 30 decrease in fracture toughness, and significant reductions in their elastic modulus [94]. In a solution [71] and in ectopic sites, osteopontin is an inhibitor of the formation and growth of HA crystals [157]. FGF23 deficiency leads to renal phosphate wasting, elevated circulating phosphate levels and surprisingly, rickets (hypomineralization). FGF23 KO mice over-expres
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Tta calculations and symmetric docking calculations starting from the CS-Rosetta monomers do not show convergence, indicating an interleaved dimer interface. The fold-and-dock protocol, supplemented by 45 RDCs, converges to a 2.5 ?structure, which shows the correct interleaved backbone topology (Supporting Information Figure 1). Very similar results were obtained for the structural genomics target
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Imized formulations . Currently, several VLP-based vaccine candidates for human diseases areImized formulations . Currently, several VLP-based vaccine candidates for human diseases are under clinical development including those directed against Influenza A virus, Norwalk virus, Ebola and Marburg viruses, Hepatitis C virus, HIV and Malaria. To date, VLP-based vaccines for human papilloma viru
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Imized formulations . Currently, several VLP-based vaccine candidates for human diseases areImized formulations . Currently, several VLP-based vaccine candidates for human diseases are under clinical development including those directed against Influenza A virus, Norwalk virus, Ebola and Marburg viruses, Hepatitis C virus, HIV and Malaria. To date, VLP-based vaccines for human papilloma viru